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Mesenchymal stem cells MSCs transplantation has been used for therapeutic applications in various diseases. Here we report MSCs can malignantly transform in vivo. The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs rBM-MSCs and the new tumor cell line, K3, was isolated from the neoplasm. The K3 cells expressed surface antigens and pluripotent genes similar to those of rBM-MSCs and presented tumor cell features. Moreover, the K3 cells contained side population cells SP like cancer stem cells CSCs , which might contribute to K3 heterogeneity and tumorigenic capacity. To investigate the metastatic potential of K3 cells, we established the nude mouse models of liver and lung metastases and isolated the corresponding metastatic cell lines K3-F4 and K3-B6. Both K3-F4 and K3-B6 cell lines with higher metastatic potential acquired more mesenchymal and stemness-related features. Epithelial-mesenchymal transition is a potential mechanism of K3-F4 and K3-B6 formation. Mesenchymal stem cells MSCs are a type of adult stem cell that possesses self-renewal and multilineage properties [ 1 ].
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My sisters married to the temple served a mission etcв. Dating is a tricky game. If you like her, and I'm assuming you do, I would suggest you continue the relationship and see how things pan out. A shitty sex life, potentially. This also means giving her something specific to do. There is no way she will may you without you going to the temple.
It's gonna end regardless not trying to be a dick, but that is what is going to happen eventuallyso be smart and cut your losses before it gets harder. How do Mormons feel about contraception. He says that I should be happy that he is giving me all the comforts of life. I feel to say, if you hear this, Amy, in time, it will all come round right. I have rediscovered what I love about the church but choose not to attend or participate. I've been married to a doctor for 5 years now been together for 11 years and he is in his first year of Anaesthetics. Sexuality is the enemy of romance, and romance is amazing. That's probably true, and that would be a great thing for her, but they wouldn't see it that way.
